Shawkat and Arteta's initial draft of the script initially focused on a couple over the course of a year-and-a-half, between a man and a woman, deciding to have sex every hour on the hour to find intimacy. Shawkat, who was cast in the lead role, met with actors, who were uncomfortable with the idea. The two initially cast Laia Costa, whom they felt that she had just the right grasp on the character, and that Costa only agreed to take on the role if she could remain on set during the entire twenty-four-hour shoot. Arteta and Shawkat decided to re-write the role for a woman. In September 2016, it was announced Shawkat and Costa had been cast in the film, with Arteta directing. In addition, Mae Whitman, Hong Chau, Kate Berlant, Lindsay Burdge, Kumail Nanjiani, with Mark Duplass and Jay Duplass rounded out the film's cast. Mark Duplass and Jay Duplas would also serve as producers under their Duplass Brothers Productions banner. At the same time, principal photography commenced, and took place over the course of nine days, with majority of the film being shot over the course of twenty-four hours. All of the dialogue was improvised.
The film stars Shawkat, Costa, Mae Whitman, Hong Chau, Berlant, Burdge, Nanjiani, with Mark and Jay Duplass. Terrifically naturalistic performances were given by the cast, especially from Shawkat and Costa that conveyed an intimacy and humanity that is certainly lacking in most Hollywood comedies now days. In this quirky indie feature, Shawkat searches for meaning and passion in a swirl of Hollywood malaise and ironically may have finally found a character who can reveal the shades of her talent. After languishing in second-banana roles in State of Grace, Arrested Development, Search Party and Drunk History, Shawkat here creates a fully realised character of surprising nuance and depth. This film might finally make Shawkat and Costa movie stars.